The emerging role of intravesical botulinum toxin therapy in idiopathic detrusor overactivity

摘要: Recently there has been considerable original research into the use of botulinum neurotoxins in idiopathic detrusor overactivity (DO). This common condition underlies overactive bladder syndrome a significant proportion cases and was previously known as instability. Failure initial pharmacotherapy this leaves few effective conservative/medical treatment options. Early reports toxin (BoNT) therapy have extremely promising, appears to bridge gap such patients, before resorting invasive surgical procedures. Approximately 30 studies reported often with widely differing techniques some clinicians are beginning administer BoNT for unlicensed indication. led urgent need critically review all available evidence assess efficacy, safety technique. In addition performing systematic Medline review, abstracts presented urological, urogynaecological incontinence meetings that usage DO were analysed. Remarkable efficacy demonstrated vast majority series also used safely paediatric elderly populations. Side effects populations appear be minimal short lived. However, small remains number fundamental questions answered. Hopefully large-scale robust randomised controlled trials will provide necessary answers facilitate widespread adoption Until then caution must exercised