Clinical effects of suburothelial injection of botulinum A toxin on patients with nonneurogenic detrusor overactivity refractory to anticholinergics.

摘要: Abstract Objectives To investigate the clinical and urodynamic effects of suburothelial injection botulinum A toxin on patients with nonneurogenic detrusor overactivity. Intradetrusor has been used to treat Suburothelial might effectively inhibit occurrence overactivity mediated by sensory nerves. Methods Twenty refractory anticholinergics were enrolled treated 200 U into space. The lower urinary tract symptoms parameters assessed. Results At 3 months after treatment, 9 had regained continence (45%), 8 improvement (40%), treatment failed in (15%). 6 7 remained continent, but 5. Hematuria developed 1 patient, infection (35%), a large postvoid residual urine volume requiring catheterization (30%). Hesitancy initiation difficult urination was also noted 15 (75%). first sensation bladder filling capacity increased about two times; however, voiding efficiency reduced 50% at 2 weeks treatment. seven times baseline value decreased three greater Conclusions results this study have shown that impairs efficiency, is effective Transient retention development should be carefully monitored.