Accessibility and potency of uterotonic drugs purchased by simulated clients in four districts in India

摘要: Surveillance of drug quality for antibiotics, antiretrovirals, antimalarials and vaccines is better established than surveillance maternal health drugs in low-income countries, particularly uterotonic the prevention treatment postpartum hemorrhage. The objectives this study are to: assess private sector accessibility four used purposes (oxytocin, methylergometrine, misoprostol, valethamate bromide); to potency oxytocin methylergometrine ampoules purchased by simulated clients. was conducted Hassan Bagalkot districts Karnataka state Agra Gorakhpur Uttar Pradesh state. A sample 877 pharmacies selected (using a stratified, systematic sampling with random start), among which 847 were successfully visited. target size assessment 50 per drug, district. 100 purchases each across all districts. Successful varied In Gorakhpur, 90%-100% visits resulted purchase. Hassan, only 29%-52% Regarding potency, percent active pharmaceutical ingredient assessed using United States Pharmacopeia monograph #33 both drugs; 193 188 respectively, assessed. outside manufacturer specification ranged from 33%-40% 22%-50% Pradesh. 96% 100% specification, respectively. 54% 44% Private warrants attention. Most importantly, interventions assure needed states.