No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters

摘要: There is evidence that predisposition to cancer has a genetic component. Genetic models have suggested there at least one highly penetrant gene predisposing this disease. The oncogene MXI1 on chromosome band 10q24-25 mutated in proportion of prostate tumours and loss heterozygosity occurs site, suggesting the location tumour suppressor region. To investigate possibility may be involved inherited susceptibility cancer, we sequenced HLH ZIP regions 38 families with either three cases or two affected siblings both diagnosed below age 67 years. These are areas within which mutations been described some sporadic cancers. No were found these important coding therefore conclude does not make major contribution susceptibility.