摘要: Many tumors contain hypoxic regions. Hypoxia, in turn, is known to increase aggressiveness and be associated with treatment resistance. The two most frequently described investigated subtypes of tumor hypoxia are acute chronic. These can lead completely different hypoxia-related responses within the tumor, which could have a direct effect on development response treatment. In order accurately assess specific biological consequences, it important understand time frames best define chronic hypoxia. This article provides an overview kinetics vitro vivo Special attention was paid differentiate between methods detect spontaneous describe effects experimental There large variations reported fluctuations that dependent cell lines detection method used. addition differing levels, exposure times used induce range from 30 min several weeks no clear boundaries separating two. Evaluation consequences each subtype revealed general trend leads more aggressive phenotype. Importantly, information occurrence human needed help our understanding clinical consequences.
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