Tumor-line specific pO2 fluctuations in human melanoma xenografts

摘要: Abstract Purpose A large number of studies have demonstrated that tumors are heterogeneous in oxygen tension (pO 2 ) and may develop regions with chronically or acutely hypoxic cells during growth. In the present study, it was investigated whether experimental different lines show characteristic pO fluctuation patterns hence differ respect to kinetics acute hypoxia. Methods materials total 70 xenografted two human melanoma (A-07 R-18) were included study. Tissue measured simultaneously positions each tumor for periods at least 60 min using a two-channel fiberoptic oxygen-sensing device (OxyLite 2000, Oxford Optronix, Oxford, UK). Results The mean calculated trace, this parameter significantly greater A-07 than R-18 ( p around 3, 5, 10 mm Hg seen fraction both lines. frequency differed among individual traces from 0 20/h (A-07) 12/h (R-18) = 0.0026). absolute amplitude fluctuations ranged 1 16 33 did not between relative higher values recorded same general temporally coordinated. Conclusion Experimental patterns. result cells. hypoxia lines, line, within tumor.