Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

摘要: Restriction of the number calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases levels plasma glucose and insulin-like growth factor I (IGF-1) postpones or attenuates cancer, immunosenescence, inflammation without irreversible side effects. organisms ranging from yeast to mice, mutations IGF-I–like signaling pathways extend life-span but also cause glycogen fat accumulation dwarfism. This information suggests a new category drugs that could prevent postpone diseases aging with few adverse