Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss.
作者： Judith Aron-Wisnewsky , Joan Tordjman , Christine Poitou , Froogh Darakhshan , Danielle Hugol
DOI: 10.1210/JC.2009-0925
关键词:
摘要: Context: Macrophages accumulate in adipose tissue and possibly participate metabolic complications obesity. Macrophage number varies with site weight loss, but whether this is accompanied by phenotypic changes unknown. Objective: The objective of the study was to characterize activation state macrophages human Design/Setting: We performed a single-center prospective study. Participants/Interventions: Paired biopsies sc omental were obtained during gastric surgery 16 premenopausal obese women (aged 41.1 ± 8.6 yr; body mass index 43.8 3.4 kg/m2). Subcutaneous 3 months later subjects 10 nonobese 43.3 3.5 22.5 0.75 stained CD40, CD206, CD163 surface markers determined immunochemistry. Main Outcomes: CD40+ significantly increased obesity vs...
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