Immunological Aspectsof Pregnancy-Associated Glycoproteins

摘要: The incidence of severe cases acute E. coli mastitis in dairy cows is highest during early lactation. This phenomenon has been associated with a decreased function and numbers circulating polymorphonuclear neutrophil leukocytes (PMN). cause this impaired number poorly understood. Stress, hormonal metabolic alterations around parturition the onset lactation may play role phenomenon. Several molecules, such as cortisol beta-hydroxybutyrate have found to alter oxidative burst activity PMN parturition. Pregnancy-Associated Glycoprotein (bPAG) could also be involved. theory immunosuppression by bPAG was investigated because analogous glycoproteins produced placenta other species exert local immuno-suppression order maintain histoincompatible feto-maternal unit. production subsequent release into maternal circulation ensured binucleate cells from trophoblast starts already at implantation. However, peak levels are only reached 1 week before Due long half-life time molecule, high plasma until 2 weeks after calving. co-occurrence impairment postpartum period concentrations might support hypothesis an immunosuppressive effect PAG. Moreover, inhibitory on proliferation bovine bone marrow progenitor recently our laboratory. occurs colostrum, but its milk not clarified. It concluded that interaction between physiology reproduction one side immune cattle requires further research.