Effect of pregnancy-specific protein B on luteal cell progesterone, prostaglandin, and oxytocin production during two stages of the bovine estrous cycle.
作者： R P Del Vecchio , W D Sutherland , R G Sasser
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摘要: This experiment was designed to evaluate the effects of pregnancy-specific protein B (PSPB) on luteal cell progesterone (P 4 ), PGF 2α , PGE 2, and oxytocin secretion. Corpora lutea were collected during mid (d 10 12 ; n = 5) or late 17 18 stage estrous cycle. Large small cells (1.5 x 5 /well) treated with PSPB (0, 2.5, 5.0 μg) LH 50, 100 ng) in a 3 factorial arrangement. Cells incubated for h before adding treatments after treatments, medium at 6 h. During 18-h pretreatment period, P 2 production similar between prospective treatment groups. The did not affect production. Stage cycle (stage) time interaction <.001) indicated that mid-stage produced more than late-stage regardless stage, decreased time. ( revealed 50- 100-ng doses increased greater 0-ng dose. Production by among three however, <.01) response 5.0-μg dose PSPB. Late-stage period 6, but 12, Also, stages cells. 2.5- <.03) < .001) compared 0 μg Luteal affected These data indicate does bovine oxytocin, it increases 4, has no effect There is evidence an altering prostaglandin,
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