Deamination and decarboxylation of L-thyroxine by Chloroamine-T (CAT) in acidic medium: A mechanistic and kineitc study
作者： Aftab Aslam Parwaz Khan , Anish Khan , Abdullah M Asiri , Raviraj M Kulkarni , Sulaiman YM Alfaifi
DOI: 10.1134/S1990793116060221
关键词:
摘要: In this manuscript, we report a spectrophotometric study (at 25°C) of oxidation L-thyroxine by Chloramine T and their mechanistic pathway. The reactions are first-order with respect to both LTX CAT. Protonated Chloramine-T, TsNHCl, have been suggested as the reactive species Stochiometry reaction is 1 : 1. main products, 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl] acetaldehyde was separated, identified column chromatography, TLC FT-IR. fails initiate polymerization in presence acrylonitrile under experimental conditions employed. Investigations at different temperatures allowed determination activation parameters tentative mechanism good consistency kinetic results discussed.
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sci-hub.se 参考文章(34)
Chong Min Won, Kinetics of degradation of levothyroxine in aqueous solution and in solid state. Pharmaceutical Research. ,vol. 9, pp. 131- 137 ,(1992) , 10.1023/A:1018952415732
J Wortsman, D C Papadimitriou, M Borges, C L Defesche, Thermal inactivation of L-thyroxin. Clinical Chemistry. ,vol. 35, pp. 90- 92 ,(1989) , 10.1093/CLINCHEM/35.1.90
Abdullah M Asiri, Aftab Aslam Parwaz Khan, Anish Khan, None, Spectroscopic investigation on kinetics and mechanistic aspects to electron-transfer process into quinolinium dichromate oxidation of a high blood pressure drug captopril in acidic medium Journal of Molecular Liquids. ,vol. 203, pp. 1- 6 ,(2015) , 10.1016/J.MOLLIQ.2014.12.017
Aftab Aslam Parwaz Khan, Anish Khan, Abdullah M Asiri, Naved Azum, Malik Abdul Rub, None, Micro concentrations of Ru(III) used as homogenous catalyst in the oxidation of levothyroxine by N-bromosuccinimide and the mechanistic pathway Journal of The Taiwan Institute of Chemical Engineers. ,vol. 45, pp. 127- 133 ,(2014) , 10.1016/J.JTICE.2013.04.014
D. S. Mahadevappa, S. Ananda, N. M. Made Gowda, Kanchugarakoppal S. Rangappa, Oxidation of methionine by sodium N-chlorotoluene-p-sulphonamide in aqueous solution: a kinetic study Journal of The Chemical Society-perkin Transactions 1. ,vol. 16, pp. 39- 43 ,(1985) , 10.1039/P29850000039
Amir Waseem, Mohammad Yaqoob, Abdul Nabi, Flow-Injection Chemiluminometric Analysis of Thyroxine Hormone in a KMnO,4-Na2SO3System Journal of the Chinese Chemical Society. ,vol. 54, pp. 1505- 1510 ,(2007) , 10.1002/JCCS.200700212
Aftab Aslam Parwaz Khan, Anish Khan, Abdullah M Asiri, Naved Azum, Malik Abdul Rub, Mohammed M Rahman, Sher Bhadar Khan, None, Mechanistic Investigation of Osmium(VIII) Catalyzed Oxidation of Glutamic Acid With Sodium Salt of N-Chloro 4-Methylbenzenesulfonamide in Aqueous Media: A Practical Approach Synthesis and Reactivity in Inorganic Metal-organic and Nano-metal Chemistry. ,vol. 46, pp. 10- 18 ,(2016) , 10.1080/15533174.2013.872141
D.S. Mahadevappa, S. Ananda, A.S.A. Murthy, K.S. Rangappa, Oxidation of dimethylsulphoxide by sodium m-bromobenzene- sulphonamide: A kinetic and mechanistic study Tetrahedron. ,vol. 40, pp. 1673- 1682 ,(1984) , 10.1016/S0040-4020(01)91116-0
Puttaswamy, T. M. Anuradha, R. Ramachandrappa, N. M. Made Gowda, Oxidation of isoniazid by N-haloarenesulfonamidates in alkaline medium: A kinetic and mechanistic study International Journal of Chemical Kinetics. ,vol. 32, pp. 221- 230 ,(2000) , 10.1002/(SICI)1097-4601(2000)32:4<221::AID-KIN4>3.0.CO;2-1
M Subhashini, Determination of the protonation constant of chloramine-B. Talanta. ,vol. 32, pp. 1082- ,(1985) , 10.1016/0039-9140(85)80130-2