Micro concentrations of Ru(III) used as homogenous catalyst in the oxidation of levothyroxine by N-bromosuccinimide and the mechanistic pathway

摘要: Abstract In this paper, we report the micro concentration of Ru(III) used as homogenous catalysis in oxidation levothyroxine by N-bromosuccinimide and results a spectrophotometric investigation mechanistic pathway. Such studies are helpful gaining an insight into interaction metal ions through pathway redox reaction.The reaction stoichiometry is 1:1 presence catalyst. The products have been identified 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetaldehyde succinimide TLC, UV FTIR. rate was examined with reference to variations ionic strength, solvent polarity, free radicals, halides ions, mercuric acetate for sequestration Br − mixture addition product (RNH). constants involved mechanism were computed. overall activation parameters evaluated from Arrhenius plot. observed explored proposed mechanisms, relative laws further.