Differential gender-related susceptibility to learning and memory deficits in mice submitted to neonatal freezing microgyria model.
作者： Daniel Rial , João C. Xikota , Alessandro Miozzo , Victor E.A. Cruz , Rui D.S. Prediger
DOI: 10.1016/J.BRAINRESBULL.2009.02.003
关键词:
摘要: Sexual dimorphism during mammalian neural development seems to contribute differential gender-related incidence in malformations of cortical both humans and rodents. Here we investigated the existence susceptibility learning memory deficits brain injury severity mice submitted a microgyria model. Newborn male female C57BL/6 (P0) were unilateral freezing lesion (FL) using cooled steel probe, placed over right midline anteroposterior plane. Mice allowed survive for 12-14 weeks then behavioral tasks morphological analyses. Injured from genders did not present gross locomotor alterations, resulted similar damage mice. Additionally, selective disruption short-term social recognition was observed injured while long-term inhibitory avoidance affected by factors. These results indicate reduced social-memory induced neonatal model mice, suggesting that cognitive lesions rodents may be entirely related injury.
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