Clinical significance of serum circulating insulin-like growth factor-1 (IGF-1) mRNA in hepatocellular carcinoma

摘要: The principal aim of our study was to investigate the usefulness serum protein and circulating mRNA insulin-like growth factor-1 (IGF-1) as a diagnostic prognostic tool in hepatocellular carcinoma (HCC). Fifty-four HCC patients age- sex-matched 20 healthy controls were enrolled into this study. Pretreatment IGF-1 determined by solid-phase sandwich ELISA quantitative RT-PCR method, respectively. median age at diagnosis 60 years, range 36–77 years; where majority group male (n = 48, 88.8 %). All had cirrhotic history. Forty-six percent 25) Child-Pugh score A, 30 % 16) B or C. treated with local therapies none them received sorafenib. baseline levels significantly higher than control (p 0.04), whereas no significant difference observed for between two 0.18). Patients history HBV infection, who not treated, multiple palliative treatment 0.03, 0.05, respectively). Poor performance status < 0.001), viral etiology cirrhosis 0.03), larger tumor size 0.01), lower hemoglobin be 0.001) related worse survival. However, neither nor adverse effect on survival 0.53 0.42,