Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice
作者： Peter Van den Hooff , Martin Galvan
DOI: 10.1016/0014-2999(91)90442-S
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摘要: The actions of 5-hydroxytryptamine (5-HT) and the 5-HT1A receptor ligand MDL 73005EF on neuronal activity in CA1 region rat hippocampal slices vitro were recorded using intra- extracellular recording techniques. 5-HT (1-30 microM) hyperpolarised pyramidal neurones a concentration-dependent manner reduced membrane resistance action potential after-hyperpolarisations (AHPs). had no clear effects potential, or AHPs. However, prior application 3 microM to for 10-60 min antagonised hyperpolarisation induced by 30 but not reduction spike AHP GABAB agonist baclofen. 5-HT1A/2 antagonist spiperone (both frequency amplitude spontaneous inhibitory (bicuculline-sensitive) postsynaptic potentials. Extracellular recordings population potentials revealed that did prevent induction maintenance long-term potentiation exhibit local anaesthetic properties. It is concluded an at receptors neurones.
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