Alcohol intake modifies leptin, adiponectin and resistin serum levels and their mRNA expressions in adipose tissue of rats.

摘要: Objective Alcohol intake is known to interfere with endocrine system functions thus inducing hormonal and metabolic imbalance. The aim was investigate the impact of chronic mild alcohol concentration on serum leptin, adiponectin resistin their gene expression in epididymal adipose tissue (EAT) rats. Methods 28 days study based 3 experimental groups adult male Wistar rats: 1/ ad libitum 6 % ethanol solution pelleted diet (A), 2/ pair fed animals (PF) same caloric amount as A rats previous day (alcohol+diet), 3/ control (C) unrestricted water diet. RT-PCR method used for determination adipokines tissue, levels were measured by ELISA kits. Results group characterized reduced food energy (-10 vs C), lower body mass gain, fat smaller adipocytes. consumption significantly increased glycemia, insulin not affected. raise NEFA PF gives evidence intensified lipolysis due deficiency intake. leptin resistin, elevated present In parallel Leptin mRNA similar C regardless or pair-fed feeding. Increased positively correlated glycemia negatively size Elevated together high after moderate could contribute alteration metabolism either individually reciprocal coordination. Conclusions changed nutritional status induced significant elevation while proved only. altered glucose homeostasis.