Dietary Zinc Deficiency Exaggerates Ethanol-Induced Liver Injury in Mice: Involvement of Intrahepatic and Extrahepatic Factors

摘要: Clinical studies have demonstrated that alcoholics a lower dietary zinc intake compared to health controls. The present study was undertaken determine the interaction between deficiency and ethanol consumption in pathogenesis of alcoholic liver disease. C57BL/6N mice were subjected 8-week feeding 4 experimental liquid diets: (1) adequate diet, (2) diet plus ethanol, (3) deficient (4) ethanol. Ethanol exposure with resulted damage as indicated by elevated plasma alanine aminotransferase level increased hepatic lipid accumulation inflammatory cell infiltration. Dietary alone contents, but did not induce inflammation. showed synergistic effects on ethanol-induced damage. exaggerated genes related metabolism response. worsened imbalance pro-oxidant antioxidant enzymes expression death receptors. reduction leptin, although it affect white adipose tissue mass. also deteriorated gut permeability increase endotoxin elevation. These results demonstrate, for first time, is risk factor disease, multiple intrahepatic extrahepatic factors may mediate detrimental deficiency.