Pattern of local recurrence after conservative surgery and whole-breast irradiation

摘要: Purpose: Most recurrences in the breast after conservative surgery and whole-breast irradiation have been reported to occur within same quadrant as initial primary tumor. We analyzed long-term risk of recurrence by area irradiation. Materials Methods: In all, 1,990 women with Stage 0-II cancer were treated from 1970–1998. was ductal carcinoma situ 237, T1 1273, T2 480 patients. Of 120 local recurrences, 71 classified true (confined original quadrant) 49 elsewhere (involving outside quadrant). Kaplan-Meier methodology used calculate 5-year, 10-year, 15-year rates (95% confidence intervals parentheses). The median follow-up is 80 months. Results: There no apparent difference rate vs. recurrence, but time different. 2%, 5%, 7% (5–9%) at 5, 10, 15 years, respectively. rare 5 (1%) 10 (2%) increased 6 (3–9%) years. This half contralateral cancers 13% (10–16%). Conclusions: Recurrence for first years nearly equal even cancers. may indicate a therapeutic effect radiation other areas breast. Very long will be needed partial or without tamoxifen show that not significantly different than