Biologically active alkylated coumarins from Kayea assamica.
作者： Kyung-Hee Lee , Hee-Byung Chai , Pamela A Tamez , John M Pezzuto , Geoffrey A Cordell
DOI: 10.1016/S0031-9422(03)00243-7
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摘要: Four coumarin derivatives, theraphins A (1), B (2), C (3), and D (4), along with three known xanthones, 2-hydroxyxanthone, 1,7-dihydroxyxanthone, 5-hydroxy-1-methoxyxanthone, were isolated from the bark of Kayea assamica (Clusiaceae) native to Myanmar. Their structures determined using spectroscopic chemical techniques. The absolute configuration 1 was established by modified Mosher ester method. Theraphins (3) exhibited good cytotoxicity against Col2, KB, LNCaP human cancer cell lines. Theraphin (4) showed mild activity only KB line. coumarins also antimalarial activities.
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