Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar
作者： Nwet Nwet Win , Suresh Awale , Hiroyasu Esumi , Yasuhiro Tezuka , Shigetoshi Kadota
DOI: 10.1016/J.BMCL.2008.07.001
关键词: Cancer cell 、 In vitro 、 Stereochemistry 、 Biological activity 、 Cell culture 、 Cytotoxicity 、 Pharmacognosy 、 Aliphatic compound 、 Terpenoid 、 Chemistry
摘要: Abstract The CHCl 3 -soluble fraction of 70% EtOH extract the flower Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 μg/mL. Bioassay-guided fractionation and isolation afforded two novel compounds, kayeassamins A ( 1 ) B 2 ). Their structures were elucidated using extensive spectroscopic methods modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC 100 against 1 μM. Furthermore, both compounds inhibited migration in wound closure assay.
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