Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer.
作者： Hedayat Allah Hosseini , Ali Ahani , Hamid Galehdari , Ali Mohammad Froughmand , Masoud Hosseini
关键词:
摘要: AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer. METHODS: evaluate involvement this region cancer, we used eight microsatellite markers covering two Mb mentioned region, to perform a high-resolution analysis allele 42 cases late adenocarcinoma. RESULTS: Six these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% 53% LOH, respectively. CONCLUSION: A critical loss, close NAT2 relatively far from FEZ1 gene currently postulated as tumor suppressor region.
sci-hub.st 参考文章(40)
Sanguinetti Cj, Simpson Aj, Dias Neto E, Rapid silver staining and recovery of PCR products separated on polyacrylamide gels BioTechniques. ,vol. 17, pp. 914- 921 ,(1994)
Hu Liu, The microcell mediated transfer of human chromosome 8 into highly metastatic rat liver cancer cell line C5F World Journal of Gastroenterology. ,vol. 9, pp. 449- 453 ,(2003) , 10.3748/WJG.V9.I3.449
G Chenevix-Trench, E Woollatt, E Baker, L Hawke, R Lukeis, J C Barrett, C E Gustafson, P J Wilson, L Annab, Functional Evidence for a Colorectal Cancer Tumor Suppressor Gene at Chromosome 8p22-23 by Monochromosome Transfer Cancer Research. ,vol. 56, pp. 5238- 5245 ,(1996)
Alfred G. Knudson, Two genetic hits (more or less) to cancer Nature Reviews Cancer. ,vol. 1, pp. 157- 162 ,(2001) , 10.1038/35101031
Masashi Deguchi, Shigeki Yoshida, Stephen Kennedy, Noriyuki Ohara, Satoru Motoyama, Takeshi Maruo, Lack of Association Between Endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) Polymorphisms in a Japanese Population Journal of The Society for Gynecologic Investigation. ,vol. 12, pp. 208- 213 ,(2005) , 10.1016/J.JSGI.2005.01.008
R. Salovaara, F. Canzian, L. A. Aaltonen, P. Kristo, A. De La Chapelle, A. Hemminki, R. B. Chadwick, Semiautomated Assessment of Loss of Heterozygosity and Replication Error in Tumors Cancer Research. ,vol. 56, pp. 3331- 3337 ,(1996)
Andrea Vecchione, Hideshi Ishii, Yih-Horng Shiao, Francesco Trapasso, Massimo Rugge, Joseph F Tamburrino, Yoshiki Murakumo, Hansjuerg Alder, Carlo M Croce, Raffaele Baffa, None, Fez1/lzts1 alterations in gastric carcinoma. Clinical Cancer Research. ,vol. 7, pp. 1546- 1552 ,(2001)
B Vogelstein, E. Fearon, S. Kern, Hamilton, A. Preisinger, Y Nakamura, R White, Allelotype of colorectal carcinomas Science. ,vol. 244, pp. 207- 211 ,(1989) , 10.1126/SCIENCE.2565047
Xiaofeng Zhou, Richard C.K. Jordan, Yang Li, Bau-Lin Huang, David T.W. Wong, Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions. Cancer Genetics and Cytogenetics. ,vol. 161, pp. 86- 89 ,(2005) , 10.1016/J.CANCERGENCYTO.2005.01.004
David W Hein, Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. Mutation Research. ,vol. 506, pp. 65- 77 ,(2002) , 10.1016/S0027-5107(02)00153-7