Mycobacterium tuberculosis signal transduction system required for persistent infections.

摘要: It is estimated that nearly 2 billion people currently suffer from latent Mycobacterium tuberculosis infection. Although the key front-line antituberculosis drugs are effective in treating individuals with acute tuberculosis, these ineffective eliminating M. during persistent stages of Consequently, therapeutics directly target bacilli urgently needed. We have conducted a global analysis on group regulatory determinants may play role virulence, and identified two-component response regulator whose expression required for entrance into maintenance Inactivation this regulator, Rv0981 (termed here mprA mycobacterial persistence regulator), affected H37Rv growth vivo an organ- infection stage-specific fashion. These results indicate systems important adaptation tubercle bacillus