The seaweed Prasiola crispa (Chlorophyta) neutralizes toxic effects of Bothrops jararacussu snake venom

摘要: In Brazil, the snake genus Bothrops has many venomous species with 90 % of cases accidents. Snake bites by jararacussu result in moderate to severe envenoming, characterized hemorrhage, coagulation disorders, tissue necrosis, and death. Antivenom been regularly used for more than a century but poorly neutralizes myonecrosis. And, as consequence, victims may have their affected limbs amputated. Thus, production antivenom must be improved well alternative treatments investigated. ability four extracts green alga Prasiola crispa neutralize some toxic effects B. venom was tested. P. collected Antarctica, then extracted using solvents, dichloromethane (DCM), ethyl acetate (ETA), n-hexane (HEX), or methanol (MET). The were incubated venom, vivo (hemorrhagic, lethal, edematogenic) vitro (coagulating proteolytic) activities performed. Moreover, injected into mice before after injection extracts. Overall, inhibited all activities. MET extract less HEX, DCM ETA efficiently These latter fully protected from jararacussu-induced hemorrhage delayed death mice. Edema partially (20 %) Neutralization also observed when administered injection. results indicate that potential treat prevent thus aiding therapy.