Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents
作者： Nafizal Hossain , Herman van Halbeek , Erik De Clercq , Piet Herdewijn
DOI: 10.1016/S0040-4020(97)10431-8
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摘要: Abstract A series of 3′-β-C-branched anhydromannitol nucleosides were conveniently synthesized starting from commercially available d -ribose. The reaction sequences were: (i) conversion the protected pentofuranose to corresponding nitrohexopyranose; (ii) addition conjugated base nitrosugar formaldehyde; (iii) removal nitro group by n-tributyltin hydride treatment and (iv) Mitsunobu type alkylation introduce nucleobase. conformation intermediates final compounds deduced NMR analysis. thymine congener showed potent activity against herpes simplex virus (HSV).
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