Independent and Incremental Value of Deformation Indices for Prediction of Trastuzumab-Induced Cardiotoxicity

摘要: Background: Assessment of left ventricular systolic function is necessary during trastuzumab-based chemotherapy because potential cardiotoxicity. Deformation indices have been proposed as an adjunct to clinical risk factors and ejection fraction (EF), but the optimal parameter cutoffs are undefined. The aim this study was determine best means early detection subsequent reduction EF in patients with breast cancer treated trastuzumab. Methods: Eighty-one consecutive women (mean age, 50 6 11 years) receiving trastuzumab were prospectively studied, 37 whom received concurrent anthracyclines. Conventional echocardiographic (mitral annular [s 0 ] diastolic [e velocities) myocardial deformation (global longitudinal peak strain [GLS], global rate [GLSR-S], [GLSR-E]) measured at baseline 12 months. Cardiotoxicity defined a >10% decline percentage Results: In 24 (30%) who later developed cardiotoxicity, decreased months (GLS, P 0) 0.77 (95% confidence interval, 0.33‐1.22; = .036). Conclusions: GLS independent predictor reductions EF, incremental usual predictors for trastuzumab-induced (J Am Soc Echocardiogr 2013;26:493-8.)