Cardiac Dysfunction in the Trastuzumab Clinical Trials Experience
作者： Andrew Seidman , Clifford Hudis , Mary Kathryn Pierri , Steven Shak , Virginia Paton
DOI: 10.1200/JCO.2002.20.5.1215
关键词:
摘要: PURPOSE: This study sought to estimate cardiac dysfunction (CD) risk for patients receiving trastuzumab; characterize observed CD by severity, treatment, and clinical outcome; assess effects of baseline factors on CD; cumulative doses anthracyclines trastuzumab CD. PATIENTS AND METHODS: A retrospective review records enrolled onto any seven phase II III trials was performed. Predefined criteria were used the diagnosis, New York Heart Association functional classification system document severity. Product-limit estimates summarize anthracycline at time onset. RESULTS: Patients treated with found be an increased The incidence greatest in concomitant plus cyclophosphamide (27%). substantially lower pacli...
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