The IL-21 receptor augments Th2 effector function and alternative macrophage activation

摘要: The IL-21 receptor (IL-21R) shows significant homology with the IL-4R, and CD4+ Th2 cells are an important source of IL-21. Here we examined whether IL-21R regulates development responses in vivo. To do this, infected IL-21R–/– mice Th2-inducing pathogens Schistosoma mansoni Nippostrongylus brasiliensis influence deficiency on Th2-dependent pathology. We showed that granulomatous inflammation liver fibrosis were significantly reduced S. mansoni–infected IL-21R+/+ treated soluble IL-21R–Fc (sIL-21R–Fc). impaired response was also associated a marked reduction cytokine expression function, as evidenced by attenuated IL-4, IL-13, AMCase, Ym1, FIZZ1 (also referred to RELMα) tissues. A similarly observed following N. infection. In vitro, augmented IL-4Rα IL-13Rα1 macrophages, resulting increased mRNA arginase-1 activity stimulation IL-4 IL-13. As such, these data identify amplifier alternative macrophage activation. Collectively, results illustrate essential function for pathogen-induced responses, which may have relevance therapies both inflammatory chronic fibrotic diseases.