The high-molecular-weight human mucin is the primary salivary carrier of ABH, Le(a), and Le(b) blood group antigens.
作者： Akraporn Prakobphol , Hakon Leffler , Susan J. Fisher
DOI: 10.1177/10454411930040031001
关键词:
摘要: Because many bacteria interact with the carbohydrate portions of receptor molecules, factors controlling glycosylation probably influence ability salivary components to mediate bacterial adherence/clearance. Important sources diversity in are ABO, secretor, and Lewis genes, which code for glycosyltransferases that add specific sugar sequences termini chains glycolipids glycoproteins. We identified, by Western blotting, glycoproteins carrying ABH Le a or Leb antigens. Samples whole, unstimulated saliva were obtained from 19 subjects whose blood group was determined agglutination red cells antisera. After centrifugation, samples separated sodium dodecyl sulfate-polyacrylamide gel electrophoresis blotted onto nitrocellulose. Glycoproteins antigens identified staining blot monoclonal antisera A, B, H, Lea, The most inten...
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