Staphylococcus aureus throat carriage is associated with ABO-/secretor status.

摘要: Summary Objectives In 30% of carriers, Staphylococcus aureus colonization affects exclusively the pharynx and occurs independently from its presence in nares. This additional reservoir has implications for S. transmission, infection, decolonization. Host factors promoting throat, however, are unknown. Methods We determined pharyngeal persistent nasal carriage , ABO histo-blood group ABH secretor status phenotypes 227 individuals. Results Compared to A/non-secretors, O/non-secretor individuals were at increased risk carrying their throat (OR 6.50, 95% confidence interval 1.28–33.03, P  = 0.02) O/secretor protected 0.24, 0.07–0.77,  = 0.02). Both associations became moderately stronger after adjusting carriage, which was found be a factor univariable analysis 2.41, 1.35–4.33, p  = 0.003). Most simultaneous carriers (72%) had identical S . genotypes nose throat. Conclusions These findings consistent with in vitro studies that proposed role antigens as ligands support contribution observed population variation nasopharyngeal colonization. Based on tissue specific expression appear modulate individual patterns.