Efficacy of clorsulon for treatment of mature naturally acquired and 8-week-old experimentally induced Fasciola hepatica infections in cattle.

摘要: In a dose-titration study against experimentally induced 8-week-old Fasciola hepatica infection (study A), 20 calves were allotted to 5 groups, each of 4 calves, and treated with different doses an injectable formulation clorsulon or its vehicle: group 1--controls, no drug; 2--2 mg /kg; 3--4 drug/kg; 4--8 mg/kg; 5--16 mg/kg. Mean numbers flukes recovered from in treatment as follows: 1--112.2, 2--42, 3--4.8, 4--3.0, 5--0.2. Percentages fluke reductions for groups 2, 3, 4, ( -treated) 62.6%, 95.7%, 97.3%, 99.8%, respectively. Against naturally acquired mature (greater than 14-week-old) F infections B), total 161 7 vehicle-treated control (group 6; mean recovery = 23) 9 7) given orally containing /kg body weight. Eggs not found the feces -treated at 21 days after compared 7.4 eggs per gram (epg) 6 (control) calves. bile egg recoveries 13,532 (456 66,861) 162 (0 160) 3 calves.(ABSTRACT TRUNCATED AT 250 WORDS)