Effect of yohimbine hydrochloride on erectile impotence: a double-blind study.
作者： Jacques G. Susset , Christopher D. Tessier , John Wincze , Sudir Bansal , Chander Malhotra
DOI: 10.1016/S0022-5347(17)41308-5
关键词:
摘要: AbstractA double-blind, partial crossover study on the therapeutic effect of yohimbine hydrochloride erectile dysfunction was done in 82 sexually impotent patients. All patients underwent a multifactorial evaluation, including determination penile brachial blood pressure index, cavernosography, sacral evoked response, testosterone and prolactin determination, Derogatis sexual inventory daytime arousal test. After 1 month treatment with maximum 42.0mg. oral daily 14 per cent experienced restoration full sustained erections, 20 reported response to therapy 65 no improvement. Three positive placebo effect. Maximum takes 2 3 weeks manifest itself. Yohimbine active some arterial insufficiency unilateral reflex arc lesion, low serum levels.The 34 is encouraging, particularly V...
jurology.com 参考文章(11)
Alvaro Morales, Michael Condra, James A. Owen, David H. Surridge, Janet Fenemore, Carol Harris, Is Yohimbine Effective in the Treatment of Organic Impotence? Results of a Controlled Trial The Journal of Urology. ,vol. 137, pp. 1168- 1172 ,(1987) , 10.1016/S0022-5347(17)44436-3
M. Mas, M.A. Zahradnik, V. Martino, J.M. Davidson, Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes Brain Research. ,vol. 342, pp. 128- 134 ,(1985) , 10.1016/0006-8993(85)91360-5
D.W. Lording, Impotence: Role of Drug and Hormonal Treatment Drugs. ,vol. 15, pp. 144- 150 ,(1978) , 10.2165/00003495-197815020-00004
J.A. Owen, S.L. Nakatsu, M. Condra, D.H. Surridge, J. Fenemore, A. Morales, Sub-nanogram analysis of yohimbine and related compounds by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 342, pp. 333- 340 ,(1985) , 10.1016/S0378-4347(00)84524-7
Edmund A. Willis, Bent Ottesen, Gorm Wagner, Frank Sundler, Jan Fahrenkrug, Vasoactive intestinal polypeptide (vip) as a putative neurotransmitter in penile erection Life Sciences. ,vol. 33, pp. 383- 391 ,(1983) , 10.1016/S0024-3205(83)80013-7
Alma J. Gower, Hemmie H.G. Berendsen, Martin M. Princen, Chris L.E. Broekkamp, The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity European Journal of Pharmacology. ,vol. 103, pp. 81- 89 ,(1984) , 10.1016/0014-2999(84)90192-4
HOWARD D. WEISS, The Physiology of Human Penile Erection Annals of Internal Medicine. ,vol. 76, pp. 793- 799 ,(1972) , 10.7326/0003-4819-76-5-793
John P. Wincze, Sudhir Bansal, Chander Malhotra, Alex Balko, Jacques G. Susset, Mark Malamud, A comparison of Nocturnal Penile Tumescence and penile response to erotic stimulation during waking states in comprehensively diagnosed groups of males experiencing erectile difficulties Archives of Sexual Behavior. ,vol. 17, pp. 333- 348 ,(1988) , 10.1007/BF01541811
Margolis R, Leslie Ch, Review of studies on a mixture of nux vomica, yohimbine and methyl testosterone in the treatment of impotence. Current Therapeutic Research-clinical and Experimental. ,vol. 8, pp. 280- ,(1966)
Bruhl De, Leslie Ch, AN EFFECTIVE ANTI-IMPOTENCE AGENT. STATISTICAL EVALUATION OF 1000 REPORTED CASES. Memphis and Mid-South medical journal. ,vol. 38, pp. 379- ,(1963)