Perilipins: a diversity of intracellular lipid droplet proteins

摘要: Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs not stable lipid-depots, they active sites neutral metabolism, comprise or cholesterol cores surrounded by phospholipid monolayers containing specialized proteins. However, sizes protein compositions vary between tissue types. Proteins the perilipin family associated surfaces all carry conserved 11-mer repeat motif. Accumulating evidence indicates that perilipins involved LD formation play roles function under differing conditions. In this brief review, we summarize current knowledge metabolizing enzymes mammalian