Antigen receptor selection by editing or downregulation of V(D)J recombination
作者： David Nemazee , Kristin A Hogquist
DOI: 10.1016/S0952-7915(03)00008-6
关键词:
摘要: Clonal selection is central to immune function, but it complemented by "receptor selection", which regulates the repertoire not cell death or proliferation through control of antigen receptor gene recombination. Inappropriate receptors, such as those that are autoreactive, underexpressed, fail promote positive thymocytes B cells, stimulate secondary V-to-J recombinations destroy and replace genes. These processes play a role in lymphocyte development. Recent work on T cells has uncovered evidence for against antigen-induced editing thymocytes. Many studies suggest plays Important recent been addressing tolerance-induced
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