Randomized Controlled Trial of Light Therapy for Fatigue Following Traumatic Brain Injury

作者: Kelly L. Sinclair , Jennie L. Ponsford , John Taffe , Steven W. Lockley , Shantha M. W. Rajaratnam

DOI: 10.1177/1545968313508472

关键词:

摘要: Background. Fatigue is a common, persistent complaint following traumatic brain injury (TBI). Effective treatment not well established. Objective. The current study aimed to investigate the efficacy of 4 weeks light therapy for fatigue in patients with TBI. Methods. We undertook randomized, placebo-controlled 4-week, 45 min/morning, home-based short wavelength (blue) (max = 465 nm, 84.8 I¼W/cm2, 39.5 lux, 1.74 A� 1014 photons/cm2/s) compared yellow 574 18.5 68 1.21 1012 containing less photons range and no control group (n 10 per group) TBI who self-reported and/or sleep disturbance. Assessments secondary outcomes (self-reported daytime sleepiness, depression, quality, sustained attention) were conducted over at baseline (week 2), midway through end (weeks 2 4), cessation 8). Results. After controlling age, gender, high-intensity blue resulted reduced sleepiness during phase, evidence trend toward levels after cessation. These changes observed lower-intensity or conditions. There was also significant effect depression psychomotor vigilance performance. Conclusions. Blue appears be effective alleviating may offer noninvasive, safe, nonpharmacological alternative treatments. © Author(s) 2013.

参考文章(43)
Hyon Kim, David F. Dinges, Terry Young, Sleep-Disordered Breathing and Psychomotor Vigilance in a Community-Based Sample Sleep. ,vol. 30, pp. 1309- 1316 ,(2007) , 10.1093/SLEEP/30.10.1309
Mathias Basner, David F. Dinges, Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss. Sleep. ,vol. 34, pp. 581- 591 ,(2011) , 10.1093/SLEEP/34.5.581
Andy Field, Jeremy Miles, Discovering Statistics Using SPSS ,(2000)
Arunima Verma, Vivek Anand, Narayan P. Verma, Sleep Disorders in Chronic Traumatic Brain Injury Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. ,vol. 3, pp. 357- 362 ,(2007) , 10.5664/JCSM.26856
Jo Phipps-Nelson, Jennifer R. Redman, Derk-Jan Dijk, Shantha M. W. Rajaratnam, Daytime Exposure to Bright Light, as Compared to Dim Light, Decreases Sleepiness and Improves Psychomotor Vigilance Performance Sleep. ,vol. 26, pp. 695- 700 ,(2003) , 10.1093/SLEEP/26.6.695
Antoine U Viola, Lynette M James, Luc JM Schlangen, Derk-Jan Dijk, Blue-enriched white light in the workplace improves self-reported alertness, performance and sleep quality. Scandinavian Journal of Work, Environment & Health. ,vol. 34, pp. 297- 306 ,(2008) , 10.5271/SJWEH.1268
Joseph E. Schwartz, Lina Jandorf, Lauren B. Krupp, THE MEASUREMENT OF FATIGUE: A NEW INSTRUMENT Journal of Psychosomatic Research. ,vol. 37, pp. 753- 762 ,(1993) , 10.1016/0022-3999(93)90104-N