作者: Kelly L. Sinclair , Jennie L. Ponsford , John Taffe , Steven W. Lockley , Shantha M. W. Rajaratnam
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摘要: Background. Fatigue is a common, persistent complaint following traumatic brain injury (TBI). Effective treatment not well established. Objective. The current study aimed to investigate the efficacy of 4 weeks light therapy for fatigue in patients with TBI. Methods. We undertook randomized, placebo-controlled 4-week, 45 min/morning, home-based short wavelength (blue) (max = 465 nm, 84.8 I¼W/cm2, 39.5 lux, 1.74 A� 1014 photons/cm2/s) compared yellow 574 18.5 68 1.21 1012 containing less photons range and no control group (n 10 per group) TBI who self-reported and/or sleep disturbance. Assessments secondary outcomes (self-reported daytime sleepiness, depression, quality, sustained attention) were conducted over at baseline (week 2), midway through end (weeks 2 4), cessation 8). Results. After controlling age, gender, high-intensity blue resulted reduced sleepiness during phase, evidence trend toward levels after cessation. These changes observed lower-intensity or conditions. There was also significant effect depression psychomotor vigilance performance. Conclusions. Blue appears be effective alleviating may offer noninvasive, safe, nonpharmacological alternative treatments. © Author(s) 2013.