Ethanol can inhibit nitric oxide production
作者： Magnus G. Persson , Lars E. Gustafsson
DOI: 10.1016/0014-2999(92)94826-H
关键词:
摘要: Abstract Endogenous nitric oxide (NO) in exhaled air from anaesthetized rabbits was monitored by chemiluminescence. Ethanol (3–30 mmol kg−1 infused i.v. dose dependently reduced the levels of NO, with an IC50 23 ± 3 kg−1. L-Arginine (1 g kg−1) did not reverse effect ethanol. These results demonstrate inhibition NO formation ethanol vivo.
elsevier.com
sci-hub.se 参考文章(4)
R M Palmer, S Moncada, E A Higgs, NITRIC OXIDE: PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY Pharmacological Reviews. ,vol. 43, pp. 109- 142 ,(1991)
David S. Bredt, Paul M. Hwang, Charles E. Glatt, Charles Lowenstein, Randall R. Reed, Solomon H. Snyder, Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. ,vol. 351, pp. 714- 718 ,(1991) , 10.1038/351714A0
M. G. PERSSON, L. E. GUSTAFSSON, N. P. WIKLUND, S. MONCADA, P. HEDQVIST, Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiologica Scandinavica. ,vol. 140, pp. 449- 457 ,(1990) , 10.1111/J.1748-1716.1990.TB09021.X
L.E. Gustafsson, A.M. Leone, M.G. Persson, N.P. Wiklund, S. Moncada, Endogenous Nitric Oxide Is Present in the Exhaled Air of Rabbits, Guinea Pigs and Humans Biochemical and Biophysical Research Communications. ,vol. 181, pp. 852- 857 ,(1991) , 10.1016/0006-291X(91)91268-H