Lung tumour markers in oncology practice: a study of TPA and CA125

摘要: Several substances mark the course of lung cancer and may reliably help clinician in decision-making. This is first clinical study specifically designed to compare tissue polypeptide antigen CA 125 tumour associated antigen. Three hundred eighty-four new patients (309 males) were studied at their presentation then strictly followed-up. Anthropometric, laboratory data – including serum levels prospectively recorded. A total 1000 assays (384 pre-treatment 616 posttreatment assays) performed. Both correlated significantly with T, N M stage descriptors diagnosis (Rho: 0.200, 0.203, 0.263 0.181, 0.240, 0.276, respectively), objective response treatment 0.388 0.207, respectively). pleural neoplastic involvement was mainly an increase 0.397). strongly predictive patients' outcome, as assessed by univariate analysis survival (log-rank test: 37.24 29.01) several Cox' proportional hazards regression models. The two marker tests are similarly helpful appear complementary, given low inter-marker correlation independent prognostic capability. British Journal Cancer (2002) 87, 1112–1118. doi:10.1038/sj.bjc.6600577 www.bjcancer.com © 2002 Research UK