Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site.

摘要: Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in Chinese population to investigate potential role folate intake MTHFR gene polymorphisms gastric cancer, their interaction with infection by Helicobacter pylori tumor location. A total 767 patients newly diagnosed cancer 775 controls were selected for this study. Genotyping C677T A1298C was TaqMan assays using ABI Prism 7911HT Sequence Detection System, information on collected questionnaire. Compared CC genotype C677T, TT significantly associated decreased risk when analysis adjusted other factors. found marginal individuals carrying T allele [adjusted odds ratio (OR) = 0.83; 95% confidence interval (CI) 0.65-1.01]. detected an inverse relationship between ORs (95%CI) moderate high 0.97 (0.74-1.25) 0.64 (0.49-0.87), respectively. Moreover, H. infection, intake, location showed significant polymorphism. Our suggests protective 677TT against effect differ consumption, site.