Omics Informatics: From Scattered Individual Software Tools to Integrated Workflow Management Systems

摘要: Omic data analyses pose great informatics challenges. As an emerging subfield of bioinformatics, omics focuses on analyzing multi-omic efficiently and effectively, is gaining momentum. There are two underlying trends in the expansion landscape: explosion scattered individual tools with each which a specific task both single- multi- omic settings, fast-evolving integrated software platforms such as workflow management systems that can assemble multiple into pipelines streamline integrative analysis for complicated tasks. In this survey, we give holistic view informatics, from to systems. We not only outline landscape challenges but also sample number widely used cutting-edge algorithms readers fine-grained view. survey various (WMSs), classify them three levels WMSs simple toolkits analytical platforms, point out needs developing intelligent discuss challenges, strategies some existing work systematic evaluation tools. conclude by providing future perspectives fields new frontiers informatics.