The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism

摘要: Genetic impairment of the genes coding for three mammalian trefoil peptides resulted in severe gastrointestinal malfunctions. The also appear involved caloric metabolism. Monitoring global miRNA expression Tff3 deficient mice points to an interplay with a regulatory network. We identified 21 miRNAs that were deregulated when compared wild type strain. In silico evaluation indicated majority connected metabolic pathway “glycolysis/gluconeogenesis’’ (p=0.032), signaling including nine target Aldh9a1, Aldh2, Pck1, Aldoc, Pgam2, Pck2, Adh4, Adh5, and Fbp1. Association this is further supported by observation body mass adult KO (five months) showed clearly reduced weight. Furthermore, are localized on murine chromosomes 2 5 clusters (2A1, 2B, 5B3) suggesting coordinated control fu...