作者: Jean-Baptiste Mignardot , Olivier Beauchet , Cédric Annweiler , Christophe Cornu , Thibault Deschamps
DOI: 10.3233/JAD-132657
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摘要: Background: Cognitive impairment-related changes in postural sway increase fall risk among older adults. Better understanding this association could be helpful for prevention. Objective: To examine the center-of-pressure (COP) velocity with cognitive status and history of falls, cognitively healthy individuals (CHI), patients mild impairment (MCI), mild-to-moderate Alzheimer’s disease (MMAD). Methods: Six hundred eleven community-dwellers (77.2 ± 7.9 years; 51.8% men) were separated into CHI, MCI, MMAD participants. By computing average absolute maximal (AAMV), bounding limits COP dynamics determined while participants asked to maintain quiet stance on a force platform eyes open or closed. Age, gender, body mass index, medications, handgrip strength, Timed Up & Go score used as covariates. Results: The multivariate ANCOVA, AAMV closed conditions dependent variables, showed that highest AAMVs bound associated (p = 0.048) (i.e., lowest CHI MCI compared MMAD) falls 0.033) fallers). Conclusions: These findings identified hallmark feature impairmentrelated sway, particular MMAD. This point is special interest clinical balance assessment prevention order plan long-term targeted fall-prevention programs.