An abnormal "one-leg balance" test predicts cognitive decline during Alzheimer's disease.
作者： Yves Rolland , Gabor Abellan van Kan , Fati Nourhashemi , Sandrine Andrieu , Christelle Cantet
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摘要: Among elderly without cognitive impairment, poor physical performances have been reported to predict decline and dementia. Our aim was explore the predictive value of balance impairment for in 686 community-dwelling Alzheimer's disease (AD) patients (REAL.FR study). Being unable stand on one leg five seconds or more defined impairment. Cognitive assessed using Mini-Mental Status Examination (MMSE) score. Co-morbidities, behavioral psychological symptoms dementia (BPSD) Neuropsychiatric Inventory score, medication, level education were at hospital. MMSE every six months during two years. Linear mixed model analyses performed. At baseline, participants with (15.2% sample) significantly older, had a lower score BPSD, co-morbidities, medication. After adjustment potential covariates, presence each assessment associated mean 9.2 (1.4) points years; having no 3.8 (0.3) years (p < 0.001). An abnormal one-leg test is marker advanced predicts higher rate decline.
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