Increased interstitial histamine concentration in the psoriatic plaque.

作者: Anne Lene Krogstad , Peter Lönnroth , Göran Larson , B. Gunnar Wallin

DOI: 10.1111/1523-1747.EP12337620

关键词:

摘要: The psoriatic plaque contains an increased number of mast cells that are thought to have important role in the initiation and maintenance lesions through release mediators such as histamine, proteoglycans, lipid mediators, cytokines. It is not known, however, whether interstitial concentration histamine (and other mediators) truly plaque. aim present study was examine from involved uninvolved skin patients. Intracutaneous microdialysis performed lesional nonlesional 23 subjects. relative recovery assessed after calibration situ approximately 76% both skin. 32 +/- 3 nmol per liter 13 1 (mean SEM) (p < 0.001). Dermal estimated according Fick principle measurements arterialized venous plasma (3 liter) blood flow found be 10-fold compared with results compatible hypothesis secrete amount may contribute immunostimulation inflammation

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