Amniotic fluid bile acids in normal and pathologic pregnancy.

摘要: Radioimmunologic techniques were used to determine 2 primary bile acids (cholic and chenodeoxycholic acid) 1 secondary acid (deoxycholic from human amniotic fluid of healthy pregnant women patients with diabetes, toxemia, or intrahepatic cholestasis during pregnancy. In general, the mean concentrations in very similar those serum, although paired samples individual these values did not correlate significantly. Very high levels measured cholestasis. The about 70 times higher than controls. Amniotic cholic content was slightly elevated diabetic toxemic patients, too. Deoxycholic consistently found specimens, but there no change its concentration among various groups. this limited series significant correlation between signs fetal distress at time amniocentesis, lowest maternal serum estriol placental lactogen associated highest concentrations. condition newborn infants any patient groups studied. It thus appears that present a threat fetus, further studies are needed clarify point.