Prognostic value of extensive coronary calcium quantities in symptomatic males--a 5-year follow-up study.

作者: Stefan Möhlenkamp , Nils Lehmann , Axel Schmermund , Heiko Pump , Susanne Moebus

DOI: 10.1016/S0195-668X(02)00826-6

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摘要: Aims Coronary calcium scores (CSs) have been shown to predict future events in patients presenting for first-time evaluation of CAD. Long-term outcome data on symptomatic subjects with advanced CAD are limited. In this study, we evaluated the prognostic value very high coronary CSs males undergoing angiography and analyzed impact event definitions identification risk predictor’s. Methods results Fifty consecutive electron beam computed tomography (EBT)-based >1000 were matched 1:2 by age between 400–1000 100–400. All 150 underwent angiography. factors ascertained. Events after 5 years for: (1) hard (coronary death myocardial infarction); (2) overall (adding stroke non-coronary deaths); (3) all (including long-term revascularizations). During follow-up, 17 deaths, two infarctions three strokes occurred 21 patients; 38 43 revascularizations. earlier more frequently >1000. Left main disease was only independent predictor (hazard ratio, 4.5; 95% confidence interval, 1.1–17.8). (4.3; 1.4–13.0) (1.7; 1.1–2.5) independently predicted events. Only CSs>90thpercentile (2.5; 1.3–4.8). Conclusions Symptomatic extensive carry an even higher than other these patients, EBT-based calcified plaque burden angiographic indices severity may a complementary role predicting cardiovascular

参考文章(27)
Axel Schmermund, Dietrich Baumgart, Günter Görge, Dietrich Grönemeyer, Rainer Seibel, Kent R. Bailey, John A. Rumberger, Dietrich Paar, Raimund Erbel, Measuring the Effect of Risk Factors on Coronary Atherosclerosis: Coronary Calcium Score Versus Angiographic Disease Severity Journal of the American College of Cardiology. ,vol. 31, pp. 1267- 1273 ,(1998) , 10.1016/S0735-1097(98)00082-5
Matthew J. Budoff, Demetrios Georgiou, Alan Brody, Arthur S. Agatston, John Kennedy, Christopher Wolfkiel, William Stanford, Paul Shields, Roger J. Lewis, Warren R. Janowitz, Stuart Rich, Bruce H. Brundage, Ultrafast Computed Tomography as a Diagnostic Modality in the Detection of Coronary Artery Disease A Multicenter Study Circulation. ,vol. 93, pp. 898- 904 ,(1996) , 10.1161/01.CIR.93.5.898
Patrick G O’Malley, Allen J Taylor, Jeffrey L Jackson, Terence M Doherty, Robert C Detrano, Prognostic value of coronary electron-beam computed tomography for coronary heart disease events in asymptomatic populations. American Journal of Cardiology. ,vol. 85, pp. 945- 948 ,(2000) , 10.1016/S0002-9149(99)00906-6
Matthew J. Budoff, George A. Diamond, Paolo Raggi, Yadon Arad, Alan D. Guerci, Tracy Q. Callister, Daniel Berman, Continuous Probabilistic Prediction of Angiographically Significant Coronary Artery Disease Using Electron Beam Tomography Circulation. ,vol. 105, pp. 1791- 1796 ,(2002) , 10.1161/01.CIR.0000014483.43921.8C
Roberto Wayhs, Allan Zelinger, Paolo Raggi, High coronary artery calcium scores pose an extremely elevated risk for hard events Journal of the American College of Cardiology. ,vol. 39, pp. 225- 230 ,(2002) , 10.1016/S0735-1097(01)01737-5
Robert C. Detrano, Nathan D. Wong, Terence M. Doherty, Robert M. Shavelle, Weiyi Tang, Leonard E. Ginzton, Matthew J. Budoff, Kenneth A. Narahara, Coronary Calcium Does Not Accurately Predict Near-Term Future Coronary Events in High-Risk Adults Circulation. ,vol. 99, pp. 2633- 2638 ,(1999) , 10.1161/01.CIR.99.20.2633
J R Margolis, J T Chen, Y Kong, R H Peter, V S Behar, J A Kisslo, The diagnostic and prognostic significance of coronary artery calcification. A report of 800 cases. Radiology. ,vol. 137, pp. 609- 616 ,(1980) , 10.1148/RADIOLOGY.137.3.7444045
I. Godoy, V. Mor-Avi, L. Weinert, I. Cohen, J. Tan, R. Lang, Echocardiographic detection of regional diastolic dysfunction in patients with coronary artery disease and normal wall motion Journal of the American College of Cardiology. ,vol. 31, pp. 126- 127 ,(1998) , 10.1016/S0735-1097(98)81191-1
Axel Schmermund, John A Rumberger, Joseph F Colter, Patrick F Sheedy, Robert S Schwartz, Angiographic correlates of “spotty” coronary artery calcium detected by electron-beam computed tomography in patients with normal or near-normal coronary angiograms American Journal of Cardiology. ,vol. 82, pp. 508- 511 ,(1998) , 10.1016/S0002-9149(98)00372-5
Stanley Lemeshow, David W. Hosmer, Susanne May, Applied Survival Analysis: Regression Modeling of Time-to-Event Data ,(2008)