Dietary calcium attenuation of body fat gain during high-fat feeding in mice.

摘要: Human epidemiological studies have supported the hypothesis that a dairy food-rich diet is associated with lower fat accumulation, although prospective and intervention trials are not so conclusive contradictory data exist in animal models. The purpose of this study was to assess effects on body weight depots calcium (12 g/kg diet) wild-type mice under ad libitum high-fat (43%) normal-fat (12%) diets gain comprehension underlying mechanism effects. Our results show intake decreases depot accelerates loss diet, without differences food intake. No gene or protein expression UCP1 brown adipose tissue UCP2 white were found could be related feeding, suggesting contributed modulate by activation thermogenesis. UCP3 but increased muscle due feeding. In there decreasing proteins signalling, particular stanniocalcin 2. CaSR levels play role cytosolic adipocytes and, therefore, contribute diminution accretion. Results support anti-obesity effect dietary male indicate that, at least time-point studied, thermogenesis involved.