Long-term oral administration of cows' milk improves insulin sensitivity in rats fed a high-sucrose diet.

摘要: We evaluated the effects of long-term daily cows' milk (CM) administration on insulin resistance induced by a high-sucrose diet. F344 rats, aged 3 weeks, were divided into two groups according to diet (dextrin-fed v. sucrose-fed). These further receiving either CM or artificial (AM; isoenergetic emulsion egg white protein, maltose, lard and minerals). Rats fed sucrose- dextrin-based for 7 weeks orally administered AM at 25 ml/kg following an 8 h fast basis. Insulin sensitivity was via postprandial changes in serum glucose insulin, oral tolerance tests, fasting fructosamine concentrations. The sucrose-fed rats showed overall decrease sensitivity, but levels lower CM-treated subgroup than AM-treated subgroup. Peak concentrations highest reduced peak values comparison with administration. By area under curve analysis, after feeding loads significantly groups. also demonstrated Improved due seemed be associated duodenal GLUT2 mRNA increased propionate production within caecum.