Effects of age and ethanol on dopamine and serotonin release in the rat nucleus accumbens
作者： K. Yoshimoto , T. Yoshida , Y. Sorimachi , A. Hirano , Y. Takeuchi
DOI: 10.1016/S0031-9384(98)00067-5
关键词:
摘要: Neural functions in the nucleus accumbens (ACC) play an important role alcohol drinking behavior. In present study, we observed effects of age and ethanol (EtOH) on dopamine (DA) serotonin (5-HT) release ACC freely moving 4-, 10-, 16-month-old rats using brain microdialysis techniques. After co-perfusion with 200 mM ethanol, DA, 5-HT were decreased significantly compared to those at 4 months old. DA neurons aged less sensitive ethanol. On other hand, both basal extracellular higher than 4-month-old rats. Therefore, aging results opposite changes alcohol-induced ACC.
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