IGF-I variants

作者: Henry Lowman , Yves Dubaquie

DOI:

关键词:

摘要: IGF-I and insulin variants are provided that selectively bind to IGFBP-1 or IGFBP-3. These agonist useful, for example, improve the half-lives of insulin, respectively.

参考文章(105)
H. Terasawa, D. Kohda, H. Hatanaka, K. Nagata, N. Higashihashi, H. Fujiwara, K. Sakano, F. Inagaki, Solution structure of human insulin-like growth factor II; Recognition sites for receptors and binding proteins The EMBO Journal. ,vol. 13, pp. 5590- 5597 ,(1994) , 10.1002/J.1460-2075.1994.TB06896.X
Lawrence J. Slieker, Gerald S. Brooke, Ronald E. Chance, Li Fan, James A. Hoffmann, Daniel C. Howey, Harlan B. Long, John Mayer, James E. Shields, Karen L. Sundell, Richard D. DiMarchi, Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics Advances in Experimental Medicine and Biology. ,vol. 343, pp. 25- 32 ,(1994) , 10.1007/978-1-4615-2988-0_3
James A. Miller, Linda Owers Narhi, Qing Xin Hua, Robert Rosenfeld, Tsutomu Arakawa, Michael Rohde, Steve Prestrelski, Scott Lauren, Kendall S. Stoney, Oxidative refolding of IGF-1 yields two products of similar thermodynamic stability: A bifurcating protein-folding pathway Biochemistry. ,vol. 32, pp. 5203- 5213 ,(1993) , 10.1021/BI00070A032
A. Brinkman, C. Groffen, D. J. Kortleve, A. Geurts van Kessel, S. L. Drop, Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). The EMBO Journal. ,vol. 7, pp. 2417- 2423 ,(1988) , 10.1002/J.1460-2075.1988.TB03087.X
Steven W. Dodd, Henry A. Havel, Paul M. Kovach, Chitra Lakshminarayan, Martin P. Redmon, Charlene M. Sargeant, Gary R. Sullivan, John M. Beals, Reversible adsorption of soluble hexameric insulin onto the surface of insulin crystals cocrystallized with protamine: an electrostatic interaction Pharmaceutical Research. ,vol. 12, pp. 60- 68 ,(1995) , 10.1023/A:1016231019793
Matthew M. Rechler, Insulin-like growth factor binding proteins. Vitamins and Hormones Series. ,vol. 47, pp. 1- 114 ,(1993) , 10.1016/S0083-6729(08)60444-6
B.C. Cunningham, D.G. Lowe, B. Li, B.D. Bennett, J.A. Wells, Production of an atrial natriuretic peptide variant that is specific for type A receptor. The EMBO Journal. ,vol. 13, pp. 2508- 2515 ,(1994) , 10.1002/J.1460-2075.1994.TB06540.X
M L Bayne, J Applebaum, D Underwood, G G Chicchi, B G Green, N S Hayes, M A Cascieri, The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor. Journal of Biological Chemistry. ,vol. 264, pp. 11004- 11008 ,(1989) , 10.1016/S0021-9258(18)60418-1