Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampus.
作者： H.S. DHILLON , H.M. CARMAN , D. ZHANG , S.W. SCHEFF , M. RENUKA PRASAD
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摘要: Lactate and free fatty acids (FFAs) were extracted from the cortices hippocampi of rats subjected to sham operation, or mild (1.25 atm) moderate (2.0 fluid percussion (FP) injury, their total tissue concentrations measured. The elevation lactate in injured left cortex (IC) ipsilateral hippocampus (IH) was significantly greater moderate-injury than mild-injury group at most test times between 5 min 48 h after injury. Levels FFAs elevated IC IH a extent for longer period injury (up h) 20 min). In general, duration individual (palmitic, stearic, oleic, arachidonic acids) also group. contralateral (CC) (CH), (and stearic low-injury extravasation Evans blue 3 6 greatest hippocampal CA3 neuronal cell loss, but not cortical lesion volume, increased with severity These findings suggest that certain neurochemical, physiological (blood-brain barrier permeability), morphologic responses increase FP brain such relationships are consistent behavioral deficits observed
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