LPS-induced dental pulp inflammation increases expression of ionotropic purinergic receptors in rat trigeminal ganglion.
作者： Yangxi Chen , Li Zhang , Jingwen Yang , Lu Zhang , Zhi Chen
DOI: 10.1097/WNR.0000000000000193
关键词:
摘要: Severe toothache can be caused by dental pulp inflammation. The ionotropic purinergic receptor family (P2X) is reported to mediate nociception in primary afferent neurons. This study aims investigate the involvement of P2X receptors sensitization trigeminal ganglion (TG) Lipopolysaccharides were unilaterally applied upper molar rat induce Increased expression c-fos, a marker neuronal activity, was induced V1-V2 division, indicating activation TG expressions P2X2, P2X3, and P2X5 also increased division TG, primarily small-sized medium-sized Markers glutamatergic afferents, VGluT1, GABAergic GAD67, lipopolysaccharides coexpressed with present findings suggest that are upregulated as part produced
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